Colgate Sensitive Pro-Relief toothpaste gives you the freedom to forget all about the pain of sensitive teeth. Where does the pain of sensitive teeth come from? Receding gums and erosion of tooth enamel can expose thousands of tiny channels leading to the nerve center of your teeth. - When your teeth touch hot, cold or sugary substances, the sensation is transmitted directly through the tiny channels to the nerves and causes pain. How does Colgate Sensitive Pro-Relief work? Most other toothpastes for sensitive teeth primarily numb the pain. Colgate Pro-Relief Sensitive Teeth blocks the tiny channels that lead to sensitive dental nerves to help stop pain. With regular use, it builds a long-lasting protective barrier that acts as a protective covering against tooth sensitivity.